Animal Model:Article Title: Bacterial supplementation in mitigation of radiation-induced gastrointestinal damage.
Article Snippet: .. Animal model Radiation dose Probiotic composition Dosage Time of probiotic dose Outcome Reference Five-week-old, male C57Bl/6 JRj mice 12 Gy of X-rays TAI Limnospira indica PCC 8005morphotype P1 Lacticasei bacillus rhamnosus GG ATCC 53103 ~3× 107 cells (800 mg/kg) 7 × 108 cells 7 days prior to the radiation until the day of sacrifice (14 days) Prevention of dysbiosis; activation of an antioxidant defence system. .. [73] 6- to 8-week-old male C57BL/6 mice TBI 4 Gy Lactobacillus sp, Streptococcus sp, Bifidobacterium sp, 5 × 108 cfu units in 200 μl 7 days prior to the pelvic radiation until the day of sacrifice (14 days) Reduced villi and crypt damage, retention of intestinal integrity [74] Male SD (Sprague Dawley) rats Single 29 Gy dose to colorectal region Faecalibacterium prausnitzii strain A2–165 1 × 109 cfu Three days before irradiation, On the day of irradiation, 2 days after irradiation, Prevent the paracellular permeability, maintenance of colonic barrier integrity [1] 6-Week-old C57BL/ 6 male Single dose of 14 Gy abdominopelvic area Lactobacillus rhamnosus GG (LGG) 1.0 × 108 cfu (0.2 ml) 7 days, 14 days (daily) Decreased pro-inflammatory cytokines (TNF-α, IL-6, and MCP-1) in colon tissues [75] Male 6–8 weeks old C57BL/6 J mice Single TBI of 0, 4, 8, and 12 Gy Lactobacillus acidophilus LA85, Lactobacillus rhamnosus LRa05, Lactobacillus plantarum Lp90, Bifidobacterium longum BL21 and Bifidobacterium lactis BLa80, 10 billion cfu (0.1 g of powder) 10 days before irradiation, 4 days post irradiation (14 days) Partial restoration the diversity of gut microbiota, alleviation of intestinal epithelial injury [76] w1118 wild-type Drosophila melanogaster γ-Rays (100 Gy) dose rate L. reuteri DSM17938 and ATCC PTA6475 1 × 109 cfu/ ml 6 days before irradiation, which was continued after irradiation Restores normal stem cell proliferation, lowers ROS levels, and partially improves intestinal integrity [127] 6–8 weeks old, Male and female wildtype C57BL/6 J mice 8 to 9.2 Gy TBI E. faecalis L. rhamnosus B. fragilis S. aureus S. saprophyticus and S. agalactiae Oral gavage before irradiation Twice a week for 8 weeks Gastrointestinal repair [128] FMT Animal model Radiation dose Donors Volume of fecal microbiota Frequency of FMT/ schedule Outcome Reference 6–8 week old C57BL/6J Male and female mice 6.5 Gy gamma rays TBI Conventional, untreated, agematched male and female mice 1 ml of saline per 0.1 g of stool.
Periodic Counter-current Chromatography:Article Title: Bacterial supplementation in mitigation of radiation-induced gastrointestinal damage.
Article Snippet: .. Animal model Radiation dose Probiotic composition Dosage Time of probiotic dose Outcome Reference Five-week-old, male C57Bl/6 JRj mice 12 Gy of X-rays TAI Limnospira indica PCC 8005morphotype P1 Lacticasei bacillus rhamnosus GG ATCC 53103 ~3× 107 cells (800 mg/kg) 7 × 108 cells 7 days prior to the radiation until the day of sacrifice (14 days) Prevention of dysbiosis; activation of an antioxidant defence system. .. [73] 6- to 8-week-old male C57BL/6 mice TBI 4 Gy Lactobacillus sp, Streptococcus sp, Bifidobacterium sp, 5 × 108 cfu units in 200 μl 7 days prior to the pelvic radiation until the day of sacrifice (14 days) Reduced villi and crypt damage, retention of intestinal integrity [74] Male SD (Sprague Dawley) rats Single 29 Gy dose to colorectal region Faecalibacterium prausnitzii strain A2–165 1 × 109 cfu Three days before irradiation, On the day of irradiation, 2 days after irradiation, Prevent the paracellular permeability, maintenance of colonic barrier integrity [1] 6-Week-old C57BL/ 6 male Single dose of 14 Gy abdominopelvic area Lactobacillus rhamnosus GG (LGG) 1.0 × 108 cfu (0.2 ml) 7 days, 14 days (daily) Decreased pro-inflammatory cytokines (TNF-α, IL-6, and MCP-1) in colon tissues [75] Male 6–8 weeks old C57BL/6 J mice Single TBI of 0, 4, 8, and 12 Gy Lactobacillus acidophilus LA85, Lactobacillus rhamnosus LRa05, Lactobacillus plantarum Lp90, Bifidobacterium longum BL21 and Bifidobacterium lactis BLa80, 10 billion cfu (0.1 g of powder) 10 days before irradiation, 4 days post irradiation (14 days) Partial restoration the diversity of gut microbiota, alleviation of intestinal epithelial injury [76] w1118 wild-type Drosophila melanogaster γ-Rays (100 Gy) dose rate L. reuteri DSM17938 and ATCC PTA6475 1 × 109 cfu/ ml 6 days before irradiation, which was continued after irradiation Restores normal stem cell proliferation, lowers ROS levels, and partially improves intestinal integrity [127] 6–8 weeks old, Male and female wildtype C57BL/6 J mice 8 to 9.2 Gy TBI E. faecalis L. rhamnosus B. fragilis S. aureus S. saprophyticus and S. agalactiae Oral gavage before irradiation Twice a week for 8 weeks Gastrointestinal repair [128] FMT Animal model Radiation dose Donors Volume of fecal microbiota Frequency of FMT/ schedule Outcome Reference 6–8 week old C57BL/6J Male and female mice 6.5 Gy gamma rays TBI Conventional, untreated, agematched male and female mice 1 ml of saline per 0.1 g of stool.
Activation Assay:Article Title: Bacterial supplementation in mitigation of radiation-induced gastrointestinal damage.
Article Snippet: .. Animal model Radiation dose Probiotic composition Dosage Time of probiotic dose Outcome Reference Five-week-old, male C57Bl/6 JRj mice 12 Gy of X-rays TAI Limnospira indica PCC 8005morphotype P1 Lacticasei bacillus rhamnosus GG ATCC 53103 ~3× 107 cells (800 mg/kg) 7 × 108 cells 7 days prior to the radiation until the day of sacrifice (14 days) Prevention of dysbiosis; activation of an antioxidant defence system. .. [73] 6- to 8-week-old male C57BL/6 mice TBI 4 Gy Lactobacillus sp, Streptococcus sp, Bifidobacterium sp, 5 × 108 cfu units in 200 μl 7 days prior to the pelvic radiation until the day of sacrifice (14 days) Reduced villi and crypt damage, retention of intestinal integrity [74] Male SD (Sprague Dawley) rats Single 29 Gy dose to colorectal region Faecalibacterium prausnitzii strain A2–165 1 × 109 cfu Three days before irradiation, On the day of irradiation, 2 days after irradiation, Prevent the paracellular permeability, maintenance of colonic barrier integrity [1] 6-Week-old C57BL/ 6 male Single dose of 14 Gy abdominopelvic area Lactobacillus rhamnosus GG (LGG) 1.0 × 108 cfu (0.2 ml) 7 days, 14 days (daily) Decreased pro-inflammatory cytokines (TNF-α, IL-6, and MCP-1) in colon tissues [75] Male 6–8 weeks old C57BL/6 J mice Single TBI of 0, 4, 8, and 12 Gy Lactobacillus acidophilus LA85, Lactobacillus rhamnosus LRa05, Lactobacillus plantarum Lp90, Bifidobacterium longum BL21 and Bifidobacterium lactis BLa80, 10 billion cfu (0.1 g of powder) 10 days before irradiation, 4 days post irradiation (14 days) Partial restoration the diversity of gut microbiota, alleviation of intestinal epithelial injury [76] w1118 wild-type Drosophila melanogaster γ-Rays (100 Gy) dose rate L. reuteri DSM17938 and ATCC PTA6475 1 × 109 cfu/ ml 6 days before irradiation, which was continued after irradiation Restores normal stem cell proliferation, lowers ROS levels, and partially improves intestinal integrity [127] 6–8 weeks old, Male and female wildtype C57BL/6 J mice 8 to 9.2 Gy TBI E. faecalis L. rhamnosus B. fragilis S. aureus S. saprophyticus and S. agalactiae Oral gavage before irradiation Twice a week for 8 weeks Gastrointestinal repair [128] FMT Animal model Radiation dose Donors Volume of fecal microbiota Frequency of FMT/ schedule Outcome Reference 6–8 week old C57BL/6J Male and female mice 6.5 Gy gamma rays TBI Conventional, untreated, agematched male and female mice 1 ml of saline per 0.1 g of stool.
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